Investigation of Aflatoxin B1 in blood of diabetes mellitus type 2 patients

Abstract

The aim of study was investigation of aflatoxin B1 in blood serum of patients with diabetes type samples were collected from Al-Hussian hospital, Karbala province. The number of samples were (86) samples (42) samples of which were for patients with diabetes disease and (44) samples were for healthy people. The results showed that 16 (38.1%) out 42 samples that collected from patients with diabetes types of contamination with aflatoxin B1. While 13 (29.5%) sample that collected from healthy persons were contamination with aflatoxi B1 with no significant difference between them. Also, the number at blood serum collected from females and males’ patients with diabetes types and contamination with AFB1was 17 (19.7%) and 12 (13.9%) respectively. The results illustrated the AFB1 concentration in blood serum of females and males’ patients with diabetes was 1.343 ng/ml and 0.684 ng/ml respectively with significant difference between them while the concentration of toxin in blood serum of females and males was 0.133 ng/ml and 0.135 ng/ml respectively with no significant difference between them. Result: The measurement coefficient r appears there is correlation between gender and precense of AFB1 in blood serum (r =0.974 p value 0.324) it means the females more sensitive to AFB1 compare with males. Conclusion: Aflatoxin B1 contamination of blood serum patients with diabetes type 2 also AFB1 contamination blood serum of healthy persons but with low concentration compare the diabetic patients. Females more sensitive to Aflatoxin B1 compare with males. Diabetic disease led to increase the Aflatoxin B1 level in blood serum and this may be due to the ability of the AFB1 to cause tissue damage in the kidney tubules which lead to poor efficiency of the kidney function in excreting the AFB1.