Association of the IL-4 gene polymorphisms with developing of renal diseases and bacterial urinary tract infections

Abstract

The current study was designed to determine the association between the genetic polymorphism of IL-4 to the frequency of urinary tract infection as one of the contributing factors in the development of kidney infection. Out of 135 cultured urine samples, 90 bacterial isolates were obtained, distributed among 45 bacterial isolates from patients with urinary tract infection only, but the number of isolated bacterial from group of patients with urinary tract infection and kidney failure, was 45 isolates bacteria. There were significant differences (p ≤ 0.001) in the average level of interleukin 4 in the serum of the studied groups. Where the highest rates were recorded in the group of patients with renal failure only (295.81 ± 59.73) IU/ml compared to the control group (64.97 ± 36.06) IU/ml. There are significant difference in the distribution of genotypes (p < 0.001) and alleles (p < 0.001) for interleukin 4 among study groups compared to the control group. Where the C/T phenotype was dominant in the three studied groups compared to the control group from these results can be concluded that the association of different IL-4 genotypes with an increased risk of renal infection or UTI- related renal failure and there are no significant differences in the mean serum with the different genotypes of interleukin 4 at the probability level (p > 0.05).