Synthesis and Characterization of Some new Heterocyclic Derivatives from 3-Amino-4-Hydroxy Benzoic acid and Study their Biological Activity

Abstract

The aim of this study is the synthesis of heterocyclic compounds in several steps, including the first step is the reaction of 4,5-dichloro-2- phenylenediamine with 3- amino- 4- hydroxybenzoic acid to obtain an imidazole derivative (1), which reacts with salicyldehyde to give a Schiff base derivative (2). The second step involves the reaction (2) with each of (chloroacetyl chloride, alanine, sodium azide, thioglycol acid, anthranilic acid, maleic anhydride) to get (beta-lactam derivatives (3), imidazolidine (4), tetrazole(5), thiazolidine(6), hydroquinazoline(7) and oxazepine(8) ) resefectively.All prepared compounds have been diagnosed by (FT-IR and 1H-NMR ) Spectroscopy and after diagnosis of spectra compound their biological effect was studied of anticancer.