Preparation and Characterization of New Azo-Chalcone Mixed with Imidazole Ligand Coordinated with Some Chelate Complexes and Study Antitumor Activity

Abstract

A new series of some transition metal complexes were prepared from reaction mix ligands of new azo-chalcone with imidazole and Co, Ni, Cu, Zn and Cd (II) ions. New azo-chalcone prepared by two steps from reacted 4-bromo benzaldehyde with 4-aminoacetophenone to obtain chalcone after that reacted with paracetamol to result new azo-chalcone. The results show that the mole ratio (metal - ligand) is (1:2:2) for all the complexes under study. The ligand characterized by 1HNMR, mass spectrum and its complexes were characterized by microanalysis of the elements, UV-vis, FTIR, molar conduction and magnetic moment. Azo- chalcone coordinated via (N) atom of azo group and (O) atom of OH group of paracetamol with metal ions. Based on the obtained results, an octahedral geometry was proposed for all chelate complexes. The effect of the biological examination of Cd (II) complex was tested antitumor Breast cancer cells and compared with healthy cells to show the possibility of using these compounds in a therapeutic manner.