Assessment of Antimicrobial Activity of Ocimum Sanctum Against Oral Microbes- A Systematic Review

Abstract

Aim of this systematic review: To systematically evaluate the antimicrobial effect of Ocimum sanctum against oral and systemic pathogens. Methodology: Structured questions were framed; inclusion and exclusion criteria were used to filter the studies. Data bases like Pubmed, Scopus, Web of science, Science direct, Cochrane were used to search and limit the studies with respect to aim of the study. After search and removing the duplicates 220 articles were obtained and after reading the abstract 205 articles were considered as irrelevant and excluded. Full text was searched for the 15 articles and after search, for five articles full text was not available and were excluded. Ten articles considered for systematic review. Conclusion: After analysing the articles for the type of bacteria evaluated and concentrations of Ocimum sanctum used its concluded that lots of heterogenicity exists in the studies and following observations were made: Ocimum sanctum extract is effective against Gram positive organisms like S.sanguis, S.aureus and gram negative organisms like A.actinomycetem comitans, P.gingivalis. Concentrations 2%,4%,6% are effective against microorganisms. Based on toxicity levels of this concentration best suitable concentration can be selected in future clinical studies. Further studies are required to evaluate the effect of Ocimum extracts against candida, virus and other organisms like Salmonella, Klebsiella, Pseudomonas.