A comparative study between single ulcers and multiple ulcers of the cutaneous leishmaniasis parasite from an immunological point of view

Abstract

This study deals with the comparison between single ulcers and multiple ulcers of the cutaneous leishmaniasis parasite from an immunological point of viewThis study included (90) people infected with cutaneous leishmaniasis from Samarra General Hospital in Samarra city in Salah El-Din Governorate for the period from August 2021 to April 2022. (54) a person with multiple ulcersThe results of the study showed a significant increase (P≤ 0.05) in the level of Interleukin-6 (IL-6) in the single ulcer group (pg/ml 46.04 ± 15.0) and the multi-ulcer group (pg/ml 59.16 ± 18.3) compared to the control group (pg). /ml 25.42 ± 6.36), it was also observed that the increase of IL-6 in the multi-ulcer group (pg/ml 59.16 ± 18.3) compared to the single ulcer group (pg/ml 46.04 ± 15.0).The level of Interleukin-17 (IL-17) was also increased in the single ulcer group (pg/ml 47.17 ± 27.8) and the multi-ulcer group (pg/ml 87.41 ± 30.5) compared to the control group (pg/ml 38.14 ± 17.9), as it was noted. The elevation of IL-17 in the multi-ulcer group (87.41 ± 30.5 pg/ml) compared with the single ulcer group (47.17 ± 27.8 pg/ml). When comparing the immunoglobulins, the results showed that (15.6)% of the patients showed IgG specific antibodies. And (84.4%) showed that they had IgM antibodies, and the results showed that most infections were severe.The objectives of the research were represented i1- Calculating the concentrations of cellular kinetics (IL-6, IL-17) in people infected with the cutaneous leishmaniasis parasite in comparison with the control group.2- Calculating the concentrations of immunoglobulins (IgG, IgM) in people infected with the cutaneous leishmaniasis parasite compared to the control group