Effect of diabetes mellitus type 2 and Aflatoxin B1 in functional kidney and liver

Abstract

The aim of study was investigation of aflatoxin B1 in blood serum of patients with diabetes type samples were collected from Al-Hussian hospital, Karbala province. The number of samples were (86) samples (42) samples of which were for patients with diabetes disease and (44) samples were for healthy people. The results showed that 16 (38.1%) out 42 samples that collected from patients with diabetes types contamination with aflatoxin B1. While 13 (29.5%) sample that collected from healthy persons were contamination with aflatoxi B1 with no significant difference between them. Also the number at blood serum collected from females and males patients with diabetes types and contamination with AFB1was 17 (19.7%) and 12 (13.9%) respectively. The results illustrated the AFB1 concentration in blood serum of females and males patients with diabetes was 1.343 ng/ml and 0.684 ng/ml respectively with significant difference between them while the concentration of toxin in blood serum of females and males was 0.133 ng/ml and 0.135 ng/ml respectively with no significant difference between them. Measurement coefficient (r) appearance there is correlation between gender and presence of AFB1 in blood serum (r=0.974 p value 0.324) it mean the females more sensitive to AFB1 compare with male group. Males patients with diabetes and presence of AFB1 in blood serum lead to increased urea level to 42 mg/ml (abnormal level) compare (34) mg/dl in blood serum of male health. Also critinine level increased in blood serum of male patients with diabetes and born AFB1 to 1.88 mg/dl. Also uric acid level raised to 8.3 mg/dl in blood serum of male patients with diabet and born AFB1 compare with its level in male healthy without AFB1 was 5.87 mg/dl on the other hand alkaline phosphate (ALP) increased to abnormal level in ( blood serum of patients male without Aflatoxin B1) group and (female patients without Aflatoxin B1) group reached to 145.8 U/L and 147.1 U/L respectively. Also alanine amino transferase (ALT) parameter raised to (18.15 and 15.08) U/L in blood serum of males patients with diabetes with Aflatoxin B1 group and males patients with diabetes without Aflatoxin B1 group respectively. The result of measurement of AST in blood serum of males and females patients with diabetes type 2 without Aflatoxin B1 raised to 53.38 U/L and 49.82 U/L respectively.