Role of Interleukin-6 Receptor in the Clinical Status of Covid-19 Patients who Admitted to Al-Shifaa Epidemiological Hospital in Kirkuk City

Abstract

Background: The clinical presentation of COVID-19 patients is varied from mild symptoms to severe respiratory failure with multiple organ failure. Aim of the study: This study was conducted to estimate the level of IL-6 receptor and some biochemical parameters: Patients and Methods: A case-control study done in Kirkuk city 1st of December 2021 to 28th of February 2022. The study included 60 people already infected with Covid-19 virus who admitted to Al-Shifaa Epidemiological Hospital in Kirkuk city with different age groups (≥ 50 years) of both sexes. Covid-19 patients derived in to 3 groups (20 patients with mild Covid-19 infection, 20 with moderate infection and 20 with severe infection) depending on specialized physicians in internal medicine in the hospital and CT-Scan outcomes.The study also included 30 healthy control individual who apparently haven't any chronic disease with the same age range and box sexes. The clinical spectrum of COVID-19 in this study was classified according to standards in the China Center for Disease Control and Prevention, covid-19 infection ranges from being asymptomatic to being in severe acute respiratory distress. Blood sample collected from each subject enrolled in this study for determination of IL-6R by ELISA Results: The study showed that majority of patients were above 60 years, as the risk of covid-19 infection increased with age as elderly was most affected and the severity increase with the increasing in age. The study also found that males were more affected by the virus from females. The study showed that, the prevalence of smoking among Covid-19 infection was 25% (15 of 60), as compared with 13.33% in the healthy control group. The study demonstrated that obesity revealed at s risk factor of covid-19 severity. The study showed that the highest mean of IL-6R was observed in Covid-19 patients (39.68±27.92 ng/ml) and the lowest mean was in the control group (13.65±4.56 ng/ml) and the difference was highly significant at P. value: 0.0001. The study showed negative correlation between IL-6R and PO2 among Covid-19 patients. It was concluded that the highest mean of IL-6R, among Covid-19 patients and these elevations seem to reflect that the multiple organ injury. Recommended to uses IL-6R in parallel with other parameters (Ferritin, D-Dimer, CRP and LDH) as biomarkers for Covid1-9 severity.