Synthesis and Biological Activity of Novel Complexes of α, β-Unsaturated Carbonyl ligands Derived from Paracetamol

Abstract

Cobalt, Nickel and Copper complexes derived from α, β-Unsaturated carbonyl Ligands that obtained from the reaction of paracetamol with different aldehydes. Hydroxyl group on paracetamol was protected using benzyl chloride and the resulted compound was treated with different aldehydes to produce the required chalcone. Then, nitrate salts of Cobalt, Nickel and copper was reacted with the chalcone to obtain the complexes. FT-IR, 1HNMR, and 13CNMR spectroscopy were used to determine the new compounds.