Study the Change of MDA, GSH and Hb 1 Ac and Glucose in Patients with Diabetes Mellitus Type I

Abstract

A study was conducted for 6 months starting from November /2021 to April/2022 in Al-Hassan center for diabetes and endocrinology in Al-Husain medical city of Karbala. The total number of participants are (240) person include (150) patients with type I diabetes mellitus (TΙDM), the males (54) (36 %), the females 96 (64%) and (90) healthy control group, males (36) (40%), females (54) (60%). In the recent study observed, the highest rate of age group in patients with T1DM in (12-17) (48%) and (18-23) (16%) confirms that high percentage of patients are children and adolescents. Also, all patients recorded in this study is a female and their percentage was (64%) while the males was (36%) confirms the most patients were diagnosed with diabetes are female this result demonstrated a relationship between gender and type I diabetes. also revealed a relationship between weight, height and body mass index (BMI) with gender. The considerable percentage of blood group for patients was showed in O (48%) and A (25.43%). Furthermore, observed increase in level of HbA1c and glucose concentrations in diabetic patients especially in females than males compared to the control group. Also detected in most patients an increase in concentrations of (MDA) enzyme and decreased in (GSH) enzyme concentrations and this can be considered as a diagnostic feature for type 1 diabetes.