Impact of Endothelin-1 Cyclooxygenase -2(Cox-2) And Thyroid Hormones in Papillary Thyroid Carcinoma

Abstract

The most frequent endocrine cancer is thyroid cancer, ladies are 2-3 times as likely than males to have thyroid cancer. The purpose of this study is to investigate the impact of Cyclooxygenase-2 (COX-2) and Endothelin-1(ET-1) in sera of papillary thyroid cancer (PTC) patients. ET-1was analyzed utilizing ELISA (Enzyme-Linked Immunosorbent Assay) kitand spectrophotometric assays were used to determine the other biochemical parameters, thirty healthy individuals served as the study's control group, along with sixty PTC patients. The patients were split into patient groups made up of 20% men and 80% women, and a control group made up of 24% men and 76% women. Comparable (P>0.01) ET-1 levels between PTC patients and controls were found in the study's findings. In the serum of PTC patients compared to controls, COX-2 levels were substantially greater (P0.01). Additionally, the coefficients of variation percent results for patients are more accurate than in the control group for each parameter. Receiver Operator characteristics (ROC) and Area Under the Curve (AUC) were measured to evaluate sensitivity and specificity, the higher the sensitivity, the more likely the carriers of the disease will be classified correctly, while specificity cares about healthy people. PTC patients have exhibited significant (P<0.01) higher TSH, T3, and T4 levels than control.