Determination the Role of Anti Oxidized Low Density Lipoprotein Antibodies in Systemic Lupus Erthematosus Patients

Abstract

Background: Systemic lupus erythematosus (SLE) is an autoimmune, inflammatory disease, that can affect virtually every organ. Imbalance of the immune response and the production of autoantibodies as anti Anti Oxidized LDL (anti oxLDL) antibodies has a clear impact on the body’s organs and the development of complications of the disease, including cardiovascular diseases . Patients and Methods;The study included 100 SLE patients 7 males (7%) and 93 (93%) females with age range of 33.4±9.95 years attending Rheumatology Unit, Baghdad Teaching Hospital and 38 matched controls was 6 (15.8%) males and 32 (84.2%) females their mean age 34.2 + 9.1 years.. Serum oxLDL (IgM) and oxLDL (IgG) levels were assessed using an enzyme-linked immunosorbent assay (ELISA). RESULTS;The present study showed that, there was a significant differences between levels of OxLDL IgM between patients and controls groups, whereas the levels of oxLDL IgM in controls (11.56 µg/L) was higher than in patient with SLE (4.80 µg/L). P value was (0.005), while the results showed that there was a significant differences between levels of oxLDL IgG between patients and controls groups, whereas the levels of oxLDL IgG in control groups (19.91 µg/L) was higher than in patient SLE which was (9.68 µg/L), P value was (0.005).Conclusion:When compared to SLE patients, control groups had higher concentrations of the markers oxLDL IgM and oxLDL IgG . Further studies are. Needed to be implement and illustrate the role of OxLDL IgM in the process of the acceleration of atherosclerosis in SLE patients.