Isolation and Characterization of Bacterial Infections from Patients with Prostate Cancer

Abstract

Background: This study aimed to identify the most common bacterial isolation that were correlated with patients suffering from prostate cancer. Materials and Methods: During the period extending between (November 2021 to April 2022) from the Imam Hussain Center for Oncological and Hematological Diseases Directorate, urine samples were obtained from so suspected patients suffering from prostate cancer (PCa), their age were ranged from 51 to 80 years. Collected 50 urine sample. The technique utilized for identifying bacterial species was the Vitek 2 system. Out of 50 urine samples tested, it was determined that (58%) had non-significant bacterial growth and (42%) had significant bacterial growth. Results: The results of bacterial isolates were (81%) of Escherichia coli, (14.3%) of Enterobacter cloacae and (4.7%) of Klebsiella pneumoniae.  The most growth of E. coli isolates was within 8-10 Gleason score group (56%), this indicates that this category (Gs 8-10) is a risk factor and an encouragement for the growth of E. coli in prostate patients. The results of the present study showed that E. coli and Enterococcus are present in large number relatively in the urine of patients with PCa. Increased levels of these two bacteria in the urine could be a sign that PCa patients experience a significant degree of inflammation. Current study showed that Gleason score (8-10) with 25 patients (50%); and documented increasing prostate specific antigen in age group (70-79) years. also, the results revealed there were 17 (34%) patients within the overweight group and severe Gleason scores (8-10) that may indicate that being overweight is a risk factor for the severity of PCa. Conclusion: Gleason score (8-10) was the most prevalent in patients with PCa. Age group (70-79) years was the more than age group suffering from PCa. Escherichia coli isolates were most distribution among the patients.