The Impact of Follicle Stimulating Hormone Receptor (Rs6166) Gene Polymorphism on Infertility and Response to FSH Treatment in Iraqi Infertile Females

Abstract

background: infertility is a disorder of the reproductive system described by the failure to obtain a clinical pregnancy after twelve months or more of regular unprotected sexual intercourse. Aim: to investigate the effect of polymorphism on response to FSH. Material and Methods: 260 women were taken and divided into three infertile groups according to response (poor, moderate, and high) responder groups, and one healthy group that considered as control group. Hormonal analysis that involved (FSH, LH, AMH, TSH, prolactin, and E2), as well as vaginal ultrasonography for measurement of antral follicle count, also genetic analysis for calculation of allele frequency and odd ratio, the ultrasonography was repeated after six days of giving recombinant FSH. Results: minor allele frequency were highest in poor responder group, and the odd ratio was more than two for (TT) genotype. Conclusion: the FSHR polymorphisms (rs6166) considered as one of the genetic factors responsible for fluctuation in response to FSH in Iraqi infertile women.