Synthesis, Characterization and Antimicrobial Evaluation of Some new azo Compounds Derived from Thiazole Ring

Abstract

New thiazole derivatives were synthesized from the reaction of 2- aminobenzathiazole with p-aminoacetophenone to product compound [A], and the resulting product was reacted with phosphoric acid and concentrated nitric acid with stirring and cooling to form diazonium salts by means of a coupling reaction. The prepared diazonium salt was reacted with 2-hydroxynaphthaldehyde in the presence of sodium nitrate to give azo compounds [B]. then reacted with different aromatic amines such as p- methoxyaniline, 2-amino 5-(4-bromophenyl) 1,3,4- thiadiazoles, 5-bromo 2-aminobenzathiazole. These copounds character FT-IR, -1HNMR, C13NMR and studying the biological activity of some compounds towards two types of bacteria (positive and negative).