Correlation of Cytotoxic T-Lymphocyte-Associated Protein 4 and CD80 with Some Trace Elements in Preeclampsia.

Abstract

Preeclampsia (PE) is a complicated illness defined by hypertension and proteinuria after the 20th week of pregnancy, and it is the leading cause of infant morbidity and death. It is associated with many biochemical and immunological disorders. However, it is not clear what type of inflammation is involved in the onset of PE. In the present study, the serum levels of CD80 and its receptor cytotoxic T lymphocyte-associated antigen-4 (CTLA4), vitamin D (VD), and Granulocyte-macrophage colony-stimulating factor (GM-CSF) have been measured in 90 PE women and compared with 30 healthy pregnant women. The levels of these biomarkers were correlated with some cations and trace elements. The results showed an increase in CD80, CTLA4, GMCSF, and copper in PE women compared with controls. While a lower VD, and zinc were found in patients’ group. The receiver-operating characteristic (ROC) analyses validated the low VD and high CTLA4 for the diagnosis of PE in suspicious persons with good sensitivity and specificity. The overall conclusions of the present study are the presence of a state of inflammation, and deficiency of major micronutrients in PE women compared with healthy controls that need to be corrected.