Synthesis, Characterization, Theoretical Studies, and Biological Activity of (E)-4-(5-(2-(2, 4- Dihydroxy Benzy Lidene) Hy Draziny L) - 1, 3, 4-Oxadiazol-2-Y L) Benzene- 1, 2, 3-Triol and Its Complexes

Abstract

In the present study we prepared (E)-4-(5-(2-(2,4-dihydroxy benzylidene) hy draziny l)- 1,3,4-oxadiazol-2-y l) benzene- 1,2, 3-triol and its complexes. All prepared compounds were characterized by spectra of H1-NMR, mass, Fourier transform infrared (FTIR), as well as magnetic susceptibility. The magnetic studies suggest an tetrahedral and square planer geometry of the complexes, From results it was suggested square plainer geometry for Ni (II) complex and tetrahedral geometry for Fe (III) and Cr (III) complexes. HOMO-LUMO molecular orbitals analysis some quantum chemical parameters of the ligand derived from frontier molecular orbitals were studied. The ligand and its complexes has shown moderate to good activity gram-positive bacteria against (Staphylococcus aureus), gram-negative bacteria (pseudomonas).