Association of Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism with SARS‐CoV‐2 Iraqi Patients

Abstract

Coronavirus ailment SARS‐CoV‐2 the infectious of disease, purpose in the back of the presently ongoing pandemic, triggered through extreme. Angiotensin can change the enzyme (ACE) genes which can related of the improvement of severe acute the respiratory of syndrome (ARDS) of the results mortality patients. The aims of this study distribution frequency of ACE genotype related of COVID‐19 patients.

Material and Method: Fifty blood samples from every COVID‐19 patients and healthful manage crew used to be collected, then DNA used to be extracted and analyzed for (ACE genotypes and Alleles frequencies with (PCR) and by means of Gel electrophoreses the usage of 2.25 pc Agarose awareness (respectively) used to be examined

Results: For ACE gene polymorphism has 21 (42%) sufferers has Deletion / Deletion genotype, 19(38%) sufferers has Insertion/ Deletion genotype whilst eight (16%) sufferers has Insertion / Insertion genotype, there was once good sized relation between ACE genotype and COVID-19 contamination p=0.05, we determined giant of D/D genotype in managed team when in contrast with sufferers p=0.02, OR=0.2913( 0.0981 to 0.8651 which suggests an enlarge defensive impact of D/D genotype in opposition to the COVID-19 infection.

Conclusion: Genotype DI in the ACE I/D polymorphism related of some infectious price effect on COVID-19 mortality.