Molecular Analysis of CD147 Gene among Sars-Cov2 Patients and Vaccinated People in Babylon Province.

Abstract

SARS-COV2, a beta coronavirus, the virus that caused the epidemic of coronavirus illness in 2019 (Covid-19) has been discovered. in late 2019. Corona viruses various proteins have been identified. Discovered as interactors between SARS and CoV-2, and Their capacity to engage with host membrane receptors is due to spike proteins. SARS-COV attaches to cyclo philin A and identifies the CD147 receptor present on the surface of host cells (Cy PA), a ligand for CD147, via its nucleo capsid protein. The study aim to investigate the distribution and detection of SNPs CD147 gene mutations in Covid-19 patients as a receptor for virus entry and a modulator of virus entry through endocytosis. Twelve samples were shown to amplify CD147 gene. The study's findings showed that there is a considerable variance in the rates of mutations for a gene CD147, and the results of the sequencing analysis of the studied segment revealed 229 bp of the gene CD147 the presence of substitution and insertion mutations is distributed unevenly according to their positions P151, p (220-221) in the samples that were studied.