Synthesis, Identification and Anticancer Evaluation of new Heterocyclic Compounds Derived from 2-Benzimidazolylacetonitrile

Abstract

(E)-2-((3-acetylphenyl)diazenyl)-2-(1H-benzo[d]imidazole-2-ylacetonitrile (I) was prepared via diazotization of 3-aminoacetophenone and coupling of the product with 2-benzimidazolylacetonitrile, then it was reacted with terphathaldehyde to obtain bis azo-chalcone (IA). Then chalcone was reacted with deferent compounds such as urea thiobarbituric acid,acetoacetanilide,acetylacetone, 2-amino phenol,2-amino-5-methyl phenol malonitrile, ethylacetoacetate to yield azo-heterocyclic compounds (IA1-IA7). The structures of prepared compounds were characterized by FT-IR and 1H NMR 13C NMR, Mass spectroscopies. The efficacy of compound [I] was evaluated against MCF-7(human breast adenocarcinoma) cell line.