Immunological and Serological Parameters of Leukemia's Patients and Associated with Bacterial Infections

Abstract

Objective: Our research aims to evaluate correlation between WBC,IL-6, CRP and bacterial infection in patients with acute leukemia.

Method: The research took place between October 2021 and May 2022. Karbala Health Directorate / Imam Hussein Center For Oncology And Hematology. A venous blood sample of 10 mL was obtained from 104 acute leukemia patients and 50 healthy volunteers. We must follow critical blood culturing procedures, following which immunological and serological parameters must be determined (WBC,CRP and IL-6).

Results: 104 new acute leukemia (AL) cases, A total of 62 patients (59.62%) were males and 42 patients (40.38%) were females, with 48 (46.15%) diagnosed with acute lymphoblastic leukemia (ALL) and 56 (53.85%) diagnosed with acute myeloid leukemia (AML), 16 with bacterial infection and 88 without bacterial infection. 50 healthy persons, 28 persons (56%) were male and 22 persons (44%) female, the results of WBC(12.350) 103/ µl, CRP (45.031) mg/l, and IL-6(36.498) pg/Ml. In acute leukemia without bacterial infection there were some correlation between some parameters CRP and IL-6 in addition to a positive correlation (0.612). There were some differences in correlation measures in acute leukemia with bacterial infection, such as IL6 and WBC, as it was positive correlation (0.639).

Conclusions: the study were investigated high level of WBC, CRP and IL-6 in leukemia patients with bacterial infections.