Detection of Sophistication 2 Integron among K. pneumoniae Isolated from Urinary Tract Infections in Al-Najaf Hospitals

Abstract

Background: Class 2 Integron were most frequently associated with types of Enterobacteriaceae family example K. pneumoniae.

Objectives: The aims were to work out antibiotic susceptibility, resistance patterns and sophistication 2 Integron gene among K. pneumoniae Isolated from UTI Infections in Al-Najaf hospitals/Iraq.

Materials and methods: one hundred and fifty three K. pneumoniae isolates (non duplicate) were "collected from patients admitted to" the middle Kidney diseases and trasplantation in Al-Najaf during January 2020 to June 2020 and diagnosed to be had tract infections by K. pneumoniae, also of these isolated cultured on MacConkey agar, traditional biochemical test were used for primary identification and VITEK-2 system was wont to confirmed K. pneumoniae isolates suspected then disc diffusion method wont to identification Multidrug-Resistantand therefore the presence of sophistication 2 Integron was investigaed by PCR.

Results: The results of the present research elucidate that more than two-thirds of K .pneumoniae infections in female patients in comparision with male patients, also in this research, we show that Imipenem displayed most effective antimicrobial agents with sensitivity percent of 94.12%, while the lowest one is Cephalothin with sensitivity percent of 0.00%, and 43 isolates of all K. pneumoniae isolates are multidrug-resistant (MDR), of these only 5 isolates are harboring integron-class2 gene.

Conclusions: High prevalence of MDR K. pneumoniae in Al-Najaf hospitals and only 5 of these isolates are harboring integron-class2 gene. Imipenem best antimicrobial agents for K. pneumonia.