Disorder of Acid-Base Balance in ESRD and its Relation with Some Biochemical Variables

Abstract

High blood acidity begins in the kidneys when they lose their ability to filter and excrete acidic substances (hydrogen ions) or when they get rid of alkaline substances (bicarbonates) that equal excessive blood acidity [1]. Metabolic acidosis (MA) is a common disorder in patients who suffer from Chronic Kidney Disease (CKD) In the fifth stage of CKD (63%) of patients suffer from acidosis and in the fourth stage (44%) compared patients with CKD in the first stage (10%) [2]. Causes of metabolic acidosis include impaired secretion of ammonia, decreased reabsorption of bicarbonate in the tubules, insufficient production of bicarbonate, and the amount of acid synthesized in the body that is ingested with food [3]. The loss of more than (80%) of the nephron impedes the regeneration of the base through the process of ammonia formation. Metabolic acidosis usually develops when the glomerular filtration rate drops to (20-30) ml/min [4].