Evaluation of cTnI, cMYbPC3, CKMB and Reg3 beta in the patients with ACS

Abstract

Background: In patients with (ACS), it is necessary to identify a sensitive and specific biomarker in the early diagnostic and prognostic evaluation. So, it is more essential for application of appropriate acute treatment and further management. The aim of the current study is to evaluate the levels of cTnI, cMYBP-C, CK-MB and Reg3β in the diagnosis of ACS. Materials and Methods: To find the levels of cTnI, cMYBP-C, CK-MB and Reg3β we measured patients who admitted to coronary care unit (CCU). 50 patients with ST- elevation myocardial infarction (STEMI), 50 patients with non-ST elevation myocardial infarction (NSTEMI), 50 patients with unstable angina (UA) and 50 persons as control healthy group. Both of cTnI, cMYBP-C and Reg3β was investigated by ELISA method to quantity their levels While, CK-MB was investigated by immune inhibition assay. Results: The level peak of cMYBP-C was higher in STEMI (84.28±5.15) then NSTEMI (54.04 ± 6.84) and less in UA (16.02 ± 0.73) when compared with control group (15.60 ± 0.71), while cTnI was higher in STEMI (8.31 ± 0.84) then NSTEMI (7.62 ± 0.91) and less in UA (0. 688 ± 0.03) when compared with control group (15.60 ± 0.71). On the other hand, the mean of CK-MB in STEMI was (102.54 ± 9.42) U/L, (99.48 ± 9.15) in NSTEMI, (15.28 ± 6.15) in UA and (14.26 ± 0.86) in control group. and finally, the mean of Reg3β in the same four groups was (178.20 ± 21.11) ng /L in STEMI, (174.88 ± 14.78) ng /L in NSTEMI, (84.92 ± 8.138) ng /L in UA and (60.80 ± 7.19) ng /L in control group. On the other hand, the level peak of Reg3β in STEMI was (178.20 ± 21.11) ng /L, (174.88 ± 14.78) ng /L in NSTEMI, (84.92 ± 8.138) ng /L in UA and (60.80 ± 7.19) ng /L in control group. Conclusion: Our finding showed that increase the level of cMYBP-C earlier than cTnI and CK-MB. Then it considers a good marker for diagnosis STEMI and NSTEMI. While the increase level of Reg3β related with the intensity of inflammation the cardiac muscle.