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Raghad Abdulsalam Khaleel Munaf Hashim Zalzala Wrood Salim Al-khfajy Yasir Wael Rashid Abdullah Mohammad

Abstract

Psoriasis is a common chronic skin condition characterized by the infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation. This study was designed to investigate whether ozone act as an anti-psoriatic agent in psoriasis induced by imiquimod in mice and compared this effect with olive oil. For this 21 Albino, BALB/c mice male, 8 weeks of age weighing between 25 to 40 gm were used. Psoriasis was introduced in them by treating them with imiquimod. Topical ozone treatment and treatment with olive oil were done to compare the efficacy of the ozonated oil in the experimental animals. In this study albino mice were allocated into Three groups and treated as follows: 1. The first group was named negative control olive oil group which receive 62.5mg, 5mg of olive oil topically on both back area and right ear after imiquimod application for 14 consecutive days.


2. The second group named ozone-treated group in which animals receive 62.5mg, 5mg of ozone oil on both back area and right ear after imiquimod application for 14 consecutive days.


3. The third group named control normal group in which animals receive only olive oil 62.5mg,5mg of olive oil topically on both back area and right ear after application of imiquimod cream base for 14 consecutive days.


The study result showed that ozonated oil can effectively reduce psoriasis-like skin inflammation in the experimental mice model. The level of inflammatory cytokines such as IL-17 and IL-23 were also reduced significantly in the ozone treatment group compared with the olive oil-treated one. Further, it was also shown that the spleen index and the PASI score also decreased significantly in the ozone-treated group. The NF-κB signaling pathway was also inhibited after the ozone treatment was done. Thus this study concluded that ozonated oil is a safe and effective mode of treatment in IMQ-induced psoriasis when compared with olive oil.

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Keywords

Ozonated oil, psoriasis, imiquimod induced psoriasis, inflammation

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