Immunogenetic study of herpes simplex virus; GM-CSF in female suffering from recurrent miscarriage

Abstract

Background: Granulo cyte –macrophage- colony-as stimulating -factor (GM-C.S.F) gene may be related with repeated- pregnancy- loss (RPL); among women with reproductive age.

Objective: Investigate the association between GM-CSF- rs1042658 Gene - Polymorphism and risk of RPL among Iraqi women.

Materials and Methods: Polymerase chain reaction was performed to detect HSV1 and determine; rs1042658 geno-types by (Tetra-primer- amplification -refractory –mutation, system for all specimen (one hundred-fifty) from healthy and aborted woman.

Results: Significant variation detected in distribution frequencies of both heterozygote CT, and carriage of T allele of the rs1042658 between cases and healthy groups.

Conclusion: As results of current study, GM-CSF rs1042658 gene polymorphism may be considered as a risk factor for recurrent abortion among Iraqi women.