The Effects of Fenugreek (Trigonella Foenum-Graecum), Sesame (Sesamum Indicum) and Domperidone on Weights and Some Hormones of Lactating White Female Ra

Abstract

This study was designed to investigate the effect of fenugreek, sesame and domperidone on the mammary glands of pregnant white rats (Rattus norvegicus) in different concentrations.

The results of calculating mothers’ weights show that there is an increase in the period of dosing and lactation as a result of the mothers being dosed with the materials used for the experiment compared with the control group and for all study groups. In the third week, all groups recorded an increase in the first week after dosing with the control group, but the increase in the experimental groups was greater than the control group which was clear according to the results obtained.

As for the weights, the weights were close after birth between the control group and the experiment groups, but after one week of breastfeeding, a weight difference was observed between the experimental groups and the control group. In the second week, the difference was clear as the increase was higher than in the first week between the control group and the experimental groups and in the week The third difference was clearer, as the increase was higher than the first week and the second week of lactation between the control group and the experimental groups, and the domperidone-dosed group had a higher weight than the rest of the groups which was 27.30 g.

The results of measuring the levels of serum hormones for lactating females showed that there were significant (p<0.05) differences between the different study groups compared with the control group in the case of hormones (prolactin, estrogen and dopamine) for the domperidone-dosed group, as well as the two groups dosed with fenugreek and domperidone and the dosed sesame and domperidone as for the two dosed groups Fenugreek and the sesame dose did not show any significant differences compared to all the other measured hormones, while there were no significant changes or differences (p>0.05) in the case of hormones (progesterone, FSH and LH).