Determination of Parameters Required to Enhance the Production of Prodigiosin by Serratia Marcescens with The Antimicrobial Activities Evaluation

Abstract

Prodigiosin has been recognized as an important subject of numerous extensive studies, due to its antibacterial, antifungal, antiprotozoal, antimalarial, cytotoxic, antitumor, antioxidant, and nonsteroidal anti-inflammatory activities. The aim of this study investigation and reorganization the effect of different chemical and physical factors on the production of prodigiosin by Serratia marcescens and antimicrobial activity of prodigiosin were studied. The results showed the importance of some components such as (1.5% peptone, 3% sucrose, 0.3% glycerol, 0.1% Fe2(SO4)3 and 0.1 % BaCl2) to obtain an abundant amount of prodigiosin pigment by S. marcescens. Antimicrobial test revealed that prodigiosin pigment has an inhibitory role on S. mutans, S. aureus and B. subtilis, and this effect can be increased with increasing acidity at 35°C. In conclusion, Prodigiosin has antimicrobial activity that can be used to treat some of bacterial and fungal infections and the researcher can use many compound to enhance its bioactive activity.