The role of serum IL-10 & IFNγ among women with infertility
Keywords:
female infertility, IL10, IFN- γ, ovarian dysfunction.Abstract
Infertility is one of the most important disorders in gynecology, the immune system can play a role in causing infertility in some couples. Various subsets of T cells secrete different cytokines, such as interferon (IFN)- γ which boost cell-mediated immunity. This study was aimed to assess serum level of IFNγ and IL-10, in women with infertility resulting from ovarian dysfunction and in normal matched control group. Blood samples were obtained from 75 infertile women and from 75 fertile as a control group. The serum level of IL-10 was decrease while IFN- γ evaluated using ELISA test. These finding showed that Pro& anti-inflammatory cytokines might be playing a role as a biomarker for female infertility. Additionally, it might be considered as a guide for treatment response.
