Assessment of interferon gamma and interlukine-10 among patients with celiac disease in Karbala Province.

Abstract

Celiac disease (CD), also known as "celiac sprue," is a persistent inflammatory condition that involves the small intestine, with a incidence of 1% in the majority of population. This study aimed to investigate the role of some immune parameters such interlukin-10 (IL- 10) and interferon gamma (IFN-γ) among patients with Celiac Disease. This study was conducted on a total of (60) individual in different sex and age group cases (18 males + 42 females) including (30) patients with Celiac Disease and (30) healthy individuals. CD patients were recruited at Karbala Teaching Hospital for Children, through the duration of the beginning of August 2021 till the middle of January 2022. All patients diagnosed with CD by Anti-tTG IgA test. The age range of the study population was from (2-55) years with mean age 13.4 years. Blood was withdrawn from a vein, the serum was used for immunological tests including IL-10 and IFN-γ by ELISA technique. The findings revealed that the Celiac disease patients had a significantly higher mean of tTg IgA than the healthy Group, 131.00 pg\ml vs. 1.99 pg\ml, respectively. (P.value <0.05). Celiac disease patients had a significantly higher mean of IFN-γ than the healthy Group, 245.93 pg\ml vs. 52.69 pg\ml, respectively. (P.value <0.05). Celiac disease patients had a significantly higher mean of IL-10 than the healthy Group, 34.86 pg\ml vs. 13.68 pg\ml, respectively. (P.value <0.05). There was a significant direct (positive) correlation between IL-10 and IFN-γ (p<0.01).