Effect of Piperine on Adipokine Signaling Molecules in High Fat Diet Fed Type 2 Diabetic Experimental Rats

Abstract

and Technical Sciences, Saveetha University,  Chennai, India

Abstract: Introduction: Diabetes mellitus is a disease of inadequate control of blood glucose level. Diabetes mellitus is one of the most common disease and about 10% of the whole of united states population is diagnosed with it. They are mainly classified into 3 types , type 1, type 2 and gestational diabetes out of which , type 2 diabetes is proved to be the most commonly occurring one. Treatment of type 2 diabetes is commercially done through metformin which works by lowering glucose production in liver and increases body sensitivity towards insulin. Piperine is an alkaloid used in black pepper , The distinctive biting quality of black pepper is due to piperine. Piperine offers a wide range of pharmacological actions and health advantages, especially when used to treat chronic conditions. Some of these advantages include the treatment of hepatic steatosis and the lowering of insulin resistance. Albino male wistar rats have used in our study , it has been the first and the most popular choice for leading pharmaceutical , chemical and contact research due to its smaller size and high rate of survival

Aim and Objective:

To analyze the effect of piperine on adipokine signaling molecules in high fat diet fed type 2 experimental rats

Materials and Methods:

A healthy adult male albino rats of wistar strain weighing about 180-200g following the national guidelines and protocols has been selected to perform this study. They were given an intraperitoneal injection of streptozotocin after feeding them with high fat and later were divided into groups and treated with the prepared extract and later were subjected to undergo tests including RT- PCR  and ELISA.

Result:

Graphs were prepared from the results obtained with the adiponectin and leptin genes and were compared with the different groups of rats hence classified.

Conclusion:

Piperine holding the potent antioxidant property controls the high fat diet induced diabetes by regulating the leptin and adiponectin gene expression.