Study of the Effective Range of Drug Level Using a Nano Chitosan-Mefenamic Acid

Abstract

In the present work, the work is divided into two parts, the first include synthesis a nano Chitosan-Mefenamic acid drug, by the esterification reaction between Chitosan and Mefenamic acid drug, as it was characterized via FT-IR, ¹HNMR, ¹³CNMR and AFM techniques. The second parts; The study included, the study of drug release in two values (5.0 and 7.5) at constant temperature 310 K; where the choice of these two values depends on that the pH of the extracellular tumor is in the range of 6.5-7.5, while the endosome and lysosome are 4.5-5.5. The study gave great results, by linking the drug (Mefenamic acid) with the chitosan; because the urgent need to retain the drug within the effective range for longer time, this driving us to look for a new optimization method for drug release.