Spectrophotometric Method for The Micro determination of Naproxen in Pure and Pharmaceutical Dosage Forms Using bromophenol blue

Abstract

An easy and fast spectrophotometric method has been developed for the determination of naproxen, this method depended on the reaction between the naproxen drug with bromophenol solution in present NaOH as a base to afford a color product and the high absorption at 596 nm. Beer’s law was obeyed within 2-16 µg /mL concentration range, and molar absorbance value id 7.5985×103 L/mol.cm and Sandel sign value is 0.0303 µg /cm2. The limits of detection (LOD) and quantitation (LOQ) for the proposed method are 0.108 and 0.3608 µg/mL, respectively.