Certain Immunological Marker (Mannose Binding Lectein and Interleukin 1-Alpha) in Diabetic Patients in Wasit province

Abstract

Diabetes mellitus, or diabetes, is a group of disorders described by elevation of blood glucose that come from significance defects in the production and/or usage of insulin ability of patient's body. Diabetes and altered conditions are considered a collection of metabolic syndromes. This study was conducted on 82 samples divided into two groups: Diabetic patients (50) and (35) healthy control. This study included white blood cell level as well as neutrophils ratio. Besides that, HbA1C was estimated for all samples. Biochemical serological test includes random blood sugar test and C - reactive protein. Immunological test including (MBL, IL 1-alpha) was done using ELISA technique. In the current study, Diabetes Patients show significant increase in both family history of DM and BMI. Levels of HbA1C show increase beside RBS who shows also increase in DM patients.  White blood cells show highly significant increase, while neutrophils show moderately significant increase in DM patients. Immunological parameter including (IL1-alpha and MBL) shows a significant increase in DM patient as compared with healthy control. We conclude in this study,that the level of MBL and IL1-a increased, as well as increases in WBC count and neutrophils in DM patient combined with the elevation of HbA1C level and RBS as well as BMI value in Wasit diabetic patients, this might be the explanation of the progression in diabetes patients complications.