(E)-4-(5-(2- (4-Hydroxybenzy Lidene) Hydrazine)-1,3,4-Oxadiazol-2-Yi) Benzene-1,2,3-Triol and Its Complexes: Synthesis, Characterization, Quantum Chemical Calculations and Biological Activity

Abstract

This manuscript reports the synthesis of (E)-4-(5-(2-(2,4-hydroxy benzylidene) hy brazenly)-1,3,4-oxadiazol-2-yl) benzene-1,2,3-triol and its complexes which are novel compounds. All prepared compounds were characterized by spectra of H1-NMR, Mass spectra, Fourier transform infrared (FTIR), as well as magnetic susceptibility. The magnetic studies suggest an tetrahedral and square planer geometry of the complexes, From results it was suggested square plainer geometry for Ni (II) complex and tetrahedral geometry for Fe (III) and Cr (III) complexes. HOMO-LUMO molecular orbitals analysis some quantum chemical parameters of the ligand derived from frontier molecular orbitals were studied. The ligand and its complexes have shown moderate to good activity as antibacterial against gram-negative bacteria Serratia and Pseudomonas