Physiological and Biochemical Study of Nano-Gold Oxide for the Healingin Dogs.

Abstract

The purpose of this research was to evaluate the effects of a right lung middle lobe resection on lung tissue healing when treated with gold oxide nanoparticles and the harmonic scalpel. A total of 24 adult dogs were utilized. They were divided in half, with each half being the same size (control and treated group). Using a harmonic scalpel and titanium clamps, The right lung's medial lobe was taken out, preventing further bleeding and the introduction of air bubbles. Two weeks after surgery, the animals' physical and mental well-being were evaluated. On days 1, 2, 4, 8, 16, 22, 28, and 36 following surgery, interleukin-6 and tumor necrosis factor- were measured to examine their molecular activity. Clinical observations revealed that the dogs in both groups needed between two and four days to return to normal activity levels following surgery. The patient's heart rate and breathing rate were both normal prior to and throughout the operation. After the animal began to feel better, its heart rate and breathing rate increased and became irregular. Within 24 hours after the procedure was finished, everything was back to normal. Whereas the control group's heart rate and breathing rates did not change for several days after surgery, the experimental group's heart rate and breathing rates, these changes were observed in all of the treated animals. Interleukin-6 and tumor necrosis factor- were two molecules whose mean values were different in the molecular evaluation between the control and treated groups.