Genotyping polymorphism of PD-1 and PDL-1 in papillary thyroid carcinoma of Iraqi patients

Abstract

Papillary thyroid carcinoma (PTC) is the most common form of well-differentiated thyroid cancer, and the most common form of thyroid cancer to result from radiation exposure. Papillary carcinoma appears as an irregular solid or cystic mass or nodule in normal thyroid parenchyma. As the understanding of thyroid tumor formation advanced, the focus of genetic alterations shifted from single genetic mutations to molecular polymorphism and panels of multiple mutations. Aims of the study: To determine if pdl-1 and PD-1 polymorphism are frequent events and play a crucial role in papillary thyroid tumorigenesis and to correlate PDL-1 and PD-1 with other prognostic parameters such as age, sex, stage, and grade of the tumor.Results: The current study of PDL1 and PD-1 polymorphism n papillary thyroid carcinoma. regarding PD1 genotyping, in the assessment of rs11568821 SNPs, GG dominant genotype is present in about 52 % of cases, while the CC genotype is present in about 40.40 % in the assessment of rs4143815G>C SNP in the PDL-1 gene. Conclusion: We can conclude from the current study that PDL1 polymorphism that the molecular mutant genotyping CC is most dominant than other GG, GC, or deletion mutations. On the other hand, Regarding the PD-1 gene, Genotyping GG is more predominant than other GA, AA, Or deletion mutation.