Identification of ITGB3 Polymorphisms with implantation outcome during in vitro fertilization program

Abstract

Successful embryo implantation requires a competent embryo, a receptive endometrium, and synchronized communication between them. In the field of assisted reproductive technologies, determining the embryos with the best opportunity for implantation remains difficult. ITGB3 has been shown to play an important role in implantation outcomes after in vitro fertilization (IVF). In this study, the frequencies of rs4642 and rs4634 polymorphisms were investigated in 50 infertile females under IVF protocol (divided into successful implantation and failure implantation) and compared them with 25 healthy fertile females. the results of current study demonstrated statistically significant associations between the heterogenotypes rs4642 and rs4634 polymorphisms and IVF implantation failure (odds ratio [OR] 0.36, 95% confidence interval [CI]: 0.13 to 1.04, p: 0.04; and OR 0.14, 95% CI: 0.03 to 0.57, p:0.003, respectively) this indicates that the two heterogenotypes for two SNPs act as a protective factor. In conclusion, in our pilot study, a strong association between rs4642 and rs4634 polymorphisms and IVF implantation failure in Iraqi female has been detected. Female who carries the homogenotype of SNPs rs4642 and rs4634 may become susceptible to implantation failure.