Study of the Effect of Moringa Oleifera on Sperm Abnormalities in White Mice

Abstract

This study was conducted in the Cellular Genetics Laboratory - Department of Life Sciences / Faculty of Education / University of Qadisiyah from 16 February 2021 to 1/6/2021 and designed to assess the cellular genetic effects aqueous extract of Moringa oleifera on reducing the side effects of carboplatin in male laboratory mice through a study sperm aberration. Three concentrations of extract were selected to study genetic effects and these concentrations were (1500, 500, 250) mg/kg of body weight and the white mice Mus musculus were dosed for 35 days and after reaching the best dose (optimal) of extract (1500) mg/kg, which led to decreased sperm deformities, The effect of Carboplatin was studied in the same time period and at a dose of (90) mg/kg. The interaction of the optimal concentration of the aqueous extract of Moringa oleifera leaves 1500 mg/kg with carboplatin was performed on three interactions (before, together, after).  Carboplatin in case of sperm abnormalities.  Each of the overlap factors had a significant reduction in sperm abnormalities This results in the ability of the aqueous extract of Moringa oleifera leaves to counteract the damage caused by carboplatin due to sperm abnormalities. The treatment together was less than the interference treatments (before, after) in the rate of sperm abnormalities.  In addition, the results showed that the aqueous extract of Moringa oleifera leaves has a protective role because it contains powerful antioxidants in protecting sperm from abnormalities when given (before the drug, after the drug or simultaneously with the drug.