Study the effect of oxidative stress in patients with stomach ulcers in Anbar Governorate

Abstract

Background: Stomach ulcer disease (SUD) is common in most parts of the world, where ulcers are caused by inflammation of the stomach lining. SUD affects more than 10% of the world's population. It is one of the most common digestive problems. SUD may occur as a result of endothelial damage when there is an imbalance between defensive factors (gastric mucosal barrier, bicarbonate secretion, and elevated blood flow). Aggressive infectious agents (acid, pepsin, H. pylori, and refluxing bile salts). Oxidative stress is defined as a relative increase of (ROS and RNS) as compared to antioxidants. the stomach mucosa contains an effective enzymatic system that scavenges ROS and prevents them from causing havoc on the mucosa. The capacity of a non-enzymatic antioxidant defense system is reflected in TAC. SOD protects tissues in the stomach by converting the highly harmful radical superoxide (O2) to the less reactive peroxide (H2O2), which CAT can then remove to produce water and oxygen. Methods: We enrolled 60 patients divided into thirty males and thirty females with SUD and 60 healthy controls divided into thirty males and thirty females’ individuals who did not have the disease and had no history of smoking or drinking alcohol. We measure serum (Total Antioxidants, Super Oxide Dismutase, Malondialdehyde). Results: Serum (TAC, SOD, MDA). levels were significantly decreased in SUD patients compared to controls.