Preparation and Characterization of Nickel (II), Copper (II), and Zinc (II)Ion Complexes Using a new Schiff Base Ligand and Study of their Biological Activity.

Abstract

The synthesis of the novel ligands was disclosed in this study, (6-(((5-bromothiophen-2-yl) methylene) amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo {3,2,0} heptane-2-carboxylic acid). These Schiff base type ligands were synthesized from react between the 5-Bromo-2-thiophene carboxaldehyde and 6-aminopenicilic acid by Schiff base reaction, respectively. The relevant Ni (II), Cu (II), and Zn (II) complexes were produced using a molar ratio of metal chloride to ligand [1:2] M: L. Spectroscopic data was used to establish the chemical identity of ligands and their corresponding complexes (FT-IR, UV-Vis,1HNMR,13CNMR) and elemental analysis studies (magnetic susceptibility, atomic absorption). The Schiff base ligand, (L) demonstrated coordination with the central metal ion via azomethine nitrogen and B-lactam ring oxygen in mixed-ligand complexes. Sp3d2hybridization results in an octahedral form. When the biological activity the ligand and their complexes tested against Pseudomonas and Sauers microorganisms, the synthesized ligands and complexes showed substantial antibacterial efficacy.