Cancer protective Effects of L. Serriole Extract against Carcinogen Benzo (A) Pyrene in White Mice Liver: Histological Study

Abstract

This study was conducted to investigate the possibility of using the alcoholic extract of Lactuca serriole as a protective agent against the cancer-causing chemical benzopyrene, study included dividing male white mice into five groups 7 mice per group. The results showed a Significant changes were found in the normal liver structure in the group of animals that had been treated with the carcinogenic substance benzopyrene, including liver damage, which is represented by the infiltration of inflammatory cells in various places, especially around the central and inflammation cellular veins, and clear fibrosis around the portal and central veins. The research showed when mice were dosed with alcoholic extract of the wild lettuce plant L. serriola at a concentration of 0.006mg/kg ((0.003mg/kg)) 0.0015 mg/kg for 30 days and in conjunction with dosing it with the carcinogenic substance Benzo(a)pyrene at a concentration of 0.001mml, it was found that there was no pathological change in the normal structure of the liver tissue, that is, without damage to the hepatocytes and sinusoides in addition to the blood vessels compared to the control group for the first concentration 0.006mg/kg, as it was found that the histological shape was close to normal with the expansion and congestion of the hepatic portal vein in addition to the presence of vinegar Hepatocytes binucleated and the sinusoids expanded in comparison with the control group for the second concentration 0.003mg/kg and it was found from the histological shape of the liver that there were histological changes represented by the infiltration of inflammatory mononuclear cells with the dilatation of the hepatic veins and hematopoietic congestion, as well as the multinucleated cells of the focus.