Prediction of Chronic Kidney Disease in Type 2 Diabetes Mellitus patients

Abstract

Background: Chronic kidney disease CKD is a common condition that closely related to the Type 2 Diabetes Mellitus T2DM patients. thus, one of the wares complication that causing morbidity and mortality. According torelationshipofCKDandT2DM there is some cytokines that involved in development of both diseases. ZingAlpha2Glycoprotein(ZAG)is a novel cytokines synthesis and releasing from liver in certain disease as indicator for progression outcomes.

Aim of this study: The goal of this study was to estimates erumlevelso fZAGin patientswithT2DM including with and without CKD. Subject and Method: we use ELISA assay to measurements serum ZAG in this studycompressing61T2DMincluding 20haveCKDand control subjects60.

Result: Serum ZAG significantly increased in patient with CKD (106.71±15.923 ng/ml),comparingwith T2DM(88.14±9.610ng/ml)ascompering with control subject (55.1± 12.108 ng/ml) and (P-value < 0.05). Furthermore, closely correlated with Gender, BMI duration of T2DM,FBL,HbA1c,lipidprofile and liver enzyme(ALT,AST).

Conclusion: Serum concentrations of ZAG useful predictor biomarker for early diagnostic of diabetic nephropathy and it may involve in predicting theCKD outcome ofT2DM.

Abbreviations: Chronic kidney disease CKD, Type 2 Diabetes Mellitus T2DM, Zing Alpha 2 Glycoprotein ZAG, Fasting Blood Sugar FBS, Body Mass Index BMI.