The Relation of Angiopiotein-2 Serum Level and Female Unexplained Infertility

Abstract

Background: Female infertility of unknown a etiology account for 10% of the problem. The angiopoietin (ANGPTs) family as a vital angiogenic growth element Angiopiotein-2 is expressed at low levels during normal homeostasis, but the level of expression and secretion of this protein will increase during inflammation and diseases associated with high vascular leakage like sepsis, So the aim of the current study to examine the relation between angiopoietin2 and female infertility

Methods: Eighty-one blood samples were collected from women with infertility of unknown a etiology and from 81 age-matched control ladies with as minimum one live child and have no history of abortion or infertility as a control group. The concentration of the Angiopoietin-2 in the serum samples were measured by ELISA, followed the instructions of the manufacture of the KIT: Human ANG2 (Angiopoietin-2) ELISA Kit Catalogue No: RDEEH0036

Results: There is a significance differences in the mean serum concentration (Mean + SD) between the case and control group which was 2898.99, 313.93 respectively with p= 000, but there was no significance effect of the age of the infertile patient on the level of the studied marker, p > 0.05.Conclusion: Angiopoietin-2 serum concentration was higher in infertile female than normal conceiving one p< 0.05.