New Synthesis of Chloroquinoline Derivatives as Anti- Cancer Agents

Abstract

Autophagy is a cellular recycling system that degrades damaged or unneeded cellular organelles and proteins in a homeostatic manner. In the unfavorable metastatic environment, cancer cells are expected to utilise autophagy as a source of energy, and a number of clinical trials are now revealing the prospective role of chloroquine (CQ), an autophagy inhibitor, as a novel anticancer medication. CQ is frequently used in cancer treatment in conjunction with chemotherapeutic medicines and radiation. Chloroquine derivatives derived from 4, 7-dichloroquinoline and two anticancer medicines (doxorubicin and docetaxel) were synthesized and employed as anticancer agents in this study. The UV-Vis spectrophotometer, FTIR, CHN and HNMR were used to characterize chloroquine derivatives (CQ-DOX and CQ-DOC). Anticancer activity for each compound has been investigated and IC50 has recorded to be 2 µM and 0.715 µM respectively.