Detection of Bacterial and Level of CA15-3 in Serum of Patients with Breast Tumors

Abstract

Breast cancer, which is the most common type of cancer in women and the leading cause of cancer deaths in women globally, is a global problem. A growing body of research links the micro biome to the development and spread of certain cancers. The current study set out to ascertain how the development of breast cancer may be affected by the microbiome. Ages of the 170 patients with breast cancer in the research ranged from 14 to 65.. The research was done in the Iraqi city of Babil between September 10, 2021, and August 20, 2022. 50 women who were similar to the women in the sick group and were in the 25–75 age range made up the control group. Patients with benign breast lesions and breast cancer had their blood and breast tissue samples obtained. Immunological techniques were used to analyses blood samples, and the CA15-3 enzyme-linked immunosorbent assay (ELISA) was used. Patients with benign breast lesions and breast cancer had their breast tissue samples collected in order to isolate and identify microorganisms.. Gram negative bacteria were more prevalent than Gram positive bacteria, according to the results, with Klebsiella pneumonia accounting for 24% of all bacteria, Staphylococcus aureus 22%, E. coli 14%, Serratia marcescens 14%, Staphylococcus warneri 7%, Pseudomonas auroginosa 12%, and Proteus mirabilis 7% being the most prevalent. There was no difference in the concentration of CA15-3 between patients before and after chemotherapy, although it was much higher for patients than for the control before and after chemotherapy. age groups do not differ in terms of CA15-3 concentration.