Argyreia Nervosa Attenuates Insulin Resistance in Diabetic Gastrocnemius Muscle in Experimental Diabetic Rats: Role of Nrf2/Keap-1 Signaling Pathway
Keywords:
Insulin resistance, diabetes, novel method, gastrocnemius muscle , gene expression analysis , glucose metabolism, innovative technique.Abstract
Introduction:
Diabetes interferes with the body’s ability to metabolic sugar for energy. By far the most devastating aspect of diabetes is the long term complications it causes. Argyreia nervosa is a large climber known for its pharmacological properties which includes anti-microbial, analgesic, anti-inflammatory and various other properties.
Materials and Methods:
Fair groups of rats were taken, six rats in each group.The Group-1 rats were kept normal as such.Group-2 were diabetic rats. Group-3 as diabetic rats treated with A.nervosa.Group-4 rats were normal rats treated with A.nervosa. Then the animal is sacrificed and the gastrocnemius muscle is isolated. This is further analyzed through gene expression along with Real-time PCR.
Results and conclusion:
The control condition was normal.In diabetic condition NrF2 was reduced and Keap-1 gene was increased. The present study shows that STZ alters the glucose metabolism which was treated by A.nervosa.
