Studying the Effect of Zinc Oxide Nanoparticles, Banana Peel Aqueous Extract and Metformin on The Level of Glucose and Liver Enzymes in Male Rats Infected Experimentally with Diabetes

Abstract

The current study aimed to evaluate the effectiveness of the extract of zinc oxide nanoparticles and the aqueous extract of banana peels, the drug Metformin, in reducing glucose levels and liver enzymes ALT and AST in male rats with experimental diabetes, The study included bio-preparation of zinc oxide nanoparticles from banana peel extract and confirmation of their formation the nanomaterial By conducting several tests, namely, UV-vis, XRD, SEM, and preparing an aqueous extract of banana peels. The study included 25 male Albino white rats, whose weights reached (180-250) and their age ranged between (2-3) months. rats to 5 Groups and each group included 5 males, the first group was given water and diet only and the negative control group returned, the second group was injected subcutaneously with alloxan at a concentration of (100 mg/kg), and the third group was injected with alloxan and then dosed orally with an extract of zinc oxide nanoparticles at concentrations (10 mg/kg). ) respectively, and the fourth group was injected with alloxan and then dosed with an extract aqueous solution of banana peels at a concentration of (500 mg / kg), and the fifth group was injected with Oxan and then dosed orally with Metformin at a concentration of (0.1 mg / kg), noting that the injection process took place for 3 days, followed by the dosing process for a period of 30 days, once a day, where the results showed that there was A therapeutic effect of zinc oxide nanoparticles and aqueous extract of banana peels in lowering glucose levels and liver enzymes ALT and AST better than metformin in diabetic male rats.